ProDen PlaqueOff® Powder works systemically. Simply add to food daily, once it is ingested it begins to work its way out into the saliva which coats all of the teeth. This slowly begins to soften the plaque and tartar build up making it change texture, to a softer, gloopier texture. This can then be removed either through chewing or brushing. Simply add the 100% natural supplement to food daily. Each tub contains a 330mg scoop, so add to dry kibble, raw or wet food everyday. Results are usually seen in 3 - 8 weeks of daily use.